Guard John Moffitt is inactive for the Seattle Seahawks, a surprising move considering he started the past two weeks. Moffitt had been splitting time with rookie J.R. Sweezy the past two weeks. Lemuel Jeanpierre is the backup interior lineman in this game while Frank Omiyale is the backup tackle.
For the 49ers, Justin Smith is inactive, ending his string of 185 consecutive games played, which dated back to his rookie year in 2001. His absence is a huge loss.